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KMID : 1038620160340030209
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Radiation Oncology Journal
2016 Volume.34 No. 3 p.209 ~ p.215
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Organ preservation with neoadjuvant chemoradiation in patients with orbit invasive sinonasal cancer otherwise requiring exenteration
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Amsbaugh Mark J.
Yusuf Mehran
Silverman Craig
Bumpous Jeffrey
Potts Keven
Perez Cesar A.
Tennant Paul
Redman Rebecca
Dunlap Neal
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Abstract
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Purpose: We sought to determine if organ preservation (OP) with neoadjuvant chemoradiation (CRT) was feasible in patients with sinonasal cancer determined to require exenteration.
Materials and Methods: Twenty patients were determined to require exenteration for definitive treatment from 2005 to 2014. Fourteen patients underwent OP and 6 patients received exenteration with adjuvant CRT. Exenteration free survival (EFS), locoregional control (LRC), progression-free survival (PFS), and overall survival (OS) were estimated.
Results: Five patients (36%) receiving OP had complete disease response at time of surgery. With a median follow-up of 18.8 months, EFS was 62% at 2 years for patients undergoing OP. At 2 years, there were no significant differences in LRC, PFS or OS (all all p > 0.050) between the groups. Less grade 3 or greater toxicity was seen in patients undergoing OP (p = 0.003). Visual function was preserved in all patients undergoing OP.
Conclusion: For patients with sinonasal cancer, OP may avoid exenteration, offering similar disease control and improved toxicity.
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KEYWORD
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Sinonasal, Neoadjuvant, Organ preservation, Orbit, Exenteration
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